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Best Southwest American Restaurants in Tenderloin

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159 restaurants available nearby

A photo of Biscuits and Blues restaurant
1. Biscuits and Blues
4.7
Exceptional(2013)
Price: Expensive
• Mexican • Downtown / Union Square
Booked 1 time today
Biscuits and Blues in San Francisco's vibrant Theater District offers a unique blend of authentic Southern, Creole, and Cajun cuisine paired with world-class blues music. This celebrated venue, praised for its "excellent night" of entertainment and dining, is a must-visit for both locals and tourists. Patrons rave about the "amazing" Southern Fried Chicken and biscuits and the "melt-in-your-mouth" beef brisket, highlighting the quality and authenticity of the dishes. With its intimate setting and top-notch service, it's no wonder guests say, "If you like R&B, Soul and Blues music plus southern cooking, you need to go here right away!" Biscuits and Blues truly stands out as a gem in San Francisco’s culinary and cultural scene.
A photo of Matador - San Francisco restaurant
2. Matador - San Francisco
4.4
Awesome(192)
Price: Expensive
• Mexican • Downtown / Union Square
Booked 15 times today
Matador – San Francisco is a restaurant serving authentic Mexican cuisine. It offers delivery and takeout, and also provides catering services. The restaurant is recommended for lunch and dinner, and has garage and street parking. It is a good place for groups, and the attire and ambiance inside is casual. Matador – San Francisco offers full alcohol bar and the noise level during peak hours is average. The restaurant offers free WI-FI access and has outdoor seating as well.The menu at Matador – San Francisco includes classic Mexican dishes such as carnitas tacos, guacamole, mezcal with pineapple syrup and lemon, house salad with shrimp, salsa, and pozole. The waiting staff is friendly, courteous, and fast in taking orders and serving food.
A photo of Level III restaurant
3. Level III
3.7
Very Good(398)
Price: Expensive
• Mexican • Downtown / Union Square
Booked 1 time today
Experience social food and modern cocktails at a new level - Level Three. An exciting and sophisticated dining experience inside the JW Marriott San Francisco. This chic restaurant and lounge features a menu of delicious sharable plates crafted from the freshest, local, seasonal ingredients complemented with an extraordinary cocktail menu custom-created by an acclaimed local mixologist. Situated on the third floor lobby level of the hotel highlighted by a 16 story atrium, you can dine on extravagant plates like Dungeness Crab Cake Benedict, Croque Madame, Avocado Toast, "The Burger", Artisinal Grilled Cheese, Filet Mignon, and our Daily Catch!
A photo of Jasper's Corner Tap and Kitchen restaurant
4. Jasper's Corner Tap and Kitchen
3.8
Excellent(989)
Price: Moderate
• Mexican • Downtown / Union Square
Booked 3 times today
A long-time local favorite, Jasper’s Corner Tap and Kitchen serves crave-worthy New American cuisine. We feature 18 rotating local craft draft beers in addition to a seasonal lineup of handcrafted cocktails. Our scratch kitchen will delight you with home-style favorites and unique offerings, complemented with unique dishes straight from the imaginations of our talented chefs. Just steps away from famous Union Square in San Francisco and by the Curran Theater, Jasper’s welcomes sports fans, adventurous eaters, movers, shakers, and everyone in-between in an urban-style sophisticated, yet comfortable atmosphere.
A photo of House of Prime Rib restaurant
5. House of Prime Rib
4.8
Exceptional(15814)
Price: Very Expensive
• Mexican • Civic Center / Hayes Valley / Van Ness
Booked 255 times today
House of Prime Rib, nestled in the vibrant Civic Center / Hayes Valley / Van Ness neighborhood of San Francisco, is a bastion of exceptional American cuisine, specializing in an unparalleled prime rib experience. Celebrated for its 62-year legacy, this restaurant is a favorite for its "juicy and perfectly cooked" prime rib selections, from the English Cut to the King Henry Cut. Patrons rave about the "tender and flavorful" meat and the classic accompaniments like creamed spinach and Yorkshire pudding, emphasizing that it's not just a meal but an "unforgettable experience." The ambiance, described as energetic and celebratory, perfectly complements the top-notch service and old-school charm, making House of Prime Rib a must-visit for anyone seeking the quintessential American dining experience.
A photo of The Rotunda at Neiman Marcus - San Francisco restaurant
6. The Rotunda at Neiman Marcus - San Francisco
4.8
Exceptional(6053)
Price: Expensive
• Mexican • Downtown / Union Square
Booked 86 times today
The Rotunda at Neiman Marcus in San Francisco's Union Square is a quintessential destination for those seeking an exceptional American dining experience. Known for its elegant ambiance and meticulous service, The Rotunda offers a luxurious afternoon tea service that has won the hearts of locals and tourists alike. Patrons rave about the "delicious assortment of food" and "excellent ambience," highlighting the restaurant's ability to deliver a top-tier culinary experience. From the superb seafood selections like the praised shrimp and crab Louie salad to the classic American burger, every dish is crafted with excellence. Guests continually commend the Rotunda for its "outstanding service" and "beautiful setting," making it a must-visit for anyone looking to indulge in the finest American cuisine in a stunning, historic venue.
A photo of Wayfare Tavern restaurant
7. Wayfare Tavern
4.6
Exceptional(7789)
Price: Moderate
• Mexican • Financial District / Embarcadero
Booked 134 times today
At the heart of San Francisco's bustling Financial District, Wayfare Tavern stands as a beacon of American cuisine, offering a nostalgic yet refined dining experience. Chef Tyler Florence masterfully crafts a menu that captures the essence of early 20th century American fare, earning accolades from diners who rave about the "outstanding" food and service. Known for its moist and flavorful fried chicken and rustic yet elegant setting reminiscent of a Victorian parlor, Wayfare Tavern delivers a unique blend of tradition and innovation. Patrons consistently praise the "perfectly cooked" dishes and the tavern's ability to turn a meal into a cherished memory, making it a cornerstone of the San Francisco dining scene.
A photo of Original Joe's - San Francisco restaurant
8. Original Joe's - San Francisco
4.7
Exceptional(4184)
Price: Moderate
• Mexican • North Beach
Booked 91 times today
Original Joe's in San Francisco's vibrant North Beach is a true emblem of authentic Italian-American cuisine, offering a dining experience that's both classic and exceptional. Established over 80 years ago, it stands as the oldest of the Joe's restaurants nationwide, pioneering the renowned "Joe's Concept." With its iconic red leather booths and a menu celebrated for its Italian American flair, Original Joe's is a bastion of comfort food crafted with a Northern Californian twist. Glowing reviews often highlight dishes like the "best lasagna I have ever tasted" and praise its "incredible customer service." Whether it's the meatballs or the linguini and clams, each dish is a testament to the restaurant's commitment to quality and tradition, making it a must-visit for those seeking a genuine slice of San Francisco's culinary heritage.
A photo of Historic John's Grill restaurant
9. Historic John's Grill
4.7
Exceptional(7326)
Price: Expensive
• Mexican • Downtown / Union Square
Booked 103 times today
Nestled in the heart of Downtown San Francisco near Union Square, Historic John's Grill offers an exquisite seafood dining experience that has delighted guests since 1908. Known for its "expertly prepared fresh seafood," this landmark establishment is a favorite among celebrities and locals alike. Diners rave about the "amazing" lobster bisque and the "delicious" broiled halibut, highlighting the freshness and quality of the dishes. With its vibrant atmosphere and a nod to classic San Francisco charm, John's Grill continues to be a top choice for seafood lovers. As one patron put it, "Dinner was outstanding!! I had the broiled halibut which was so fresh and my husband had the Ribeye (also delicious). Our server Daniel was excellent! We will be back!!" Whether you're a local or just visiting, a meal at John's Grill is a must for anyone seeking the best seafood in the city.
A photo of Top of the Mark restaurant
10. Top of the Mark
4.3
Awesome(830)
Price: Expensive
• Mexican • Nob Hill
Booked 53 times today
Top of the Mark, perched on the 19th floor in Nob Hill, San Francisco, is a culinary and visual spectacle, making it a must-visit for aficionados of International cuisine. Celebrated as the number 1 hotel bar in California by USAToday, it offers a mesmerizing 360-degree view of the city, including landmarks like the Golden Gate Bridge. Patrons rave about the "over the top desserts" and "tantalizing appetizers" that perfectly pair with innovative cocktails. The live music and vibrant dance scene on Saturdays enhance the dining experience, making every visit memorable. As one reviewer put it, the place is “wow” from the moment you walk in, with food and service that match the breathtaking views. Join us at Top of the Mark for an unforgettable journey through International flavors and San Francisco’s charm.
‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

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