Best Southern American Restaurants in Jeffersonville

Price

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$$$
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Regions

Louisville

Neighborhoods

ButchertownClarksvilleDowntown LouisvilleEast LouisvilleFrankfort Ave - Crescent HillGermantown

Top Rated

CharmingFancyGood for business mealsGood for groupsGood for special occasionsGreat for brunch

Dining Options

All dining options

Delivery only

Takeout only

Seating Options

BarCounterStandardHigh TopOutdoor

Accessibility

Wheelchair access

74 restaurants available nearby

How are Featured results ranked

The default order for search results reflects a number of factors, including table availability, restaurant location, search criteria, and restaurant reviews and ratings. In addition, payment made by a restaurant to OpenTable is also a factor for the relative ordering of restaurants.

A photo of Steak & Bourbon - Downtown restaurant

1. Steak & Bourbon - Downtown

4.8

Exceptional(243)

$$$$Price: Very Expensive

• Southern american • West Louisville

Booked 58 times today

Steak & Bourbon - Downtown is a standout destination for authentic American cuisine in Louisville. This modern steakhouse brilliantly marries elegance with warmth, offering a refined yet inviting atmosphere that's perfect for any occasion. Diners rave about the "phenomenal steaks" and "exquisite" dishes, highlighting the culinary team's skill in delivering perfectly seared meats and creative sides. The ambiance is enriched by live jazz music, reminiscent of an upscale New York or Chicago steakhouse. Guests consistently commend the "top-notch service" and the attentive staff, ensuring a memorable dining experience. For anyone seeking a quintessential American dining adventure, Steak & Bourbon is a must-visit.

A photo of River House Restaurant & Raw Bar restaurant

2. River House Restaurant & Raw Bar

4.8

Exceptional(7574)

$$$$Price: Moderate

• Southern american • Downtown Louisville

Booked 76 times today

River House Restaurant & Raw Bar offers an unparalleled Contemporary American dining experience in Louisville, skillfully blending regional flavors with a Southern flair. The culinary creations, like the "BBQ Braised Beef Short Rib" and "Maker’s Mark Bourbon Barrel Smoked Salmon," are celebrated for their authenticity and freshness, making each dish a delightful journey for the palate. Diners rave about the "excellent service" and "picturesque view of the river," enhancing the overall dining experience. As one reviewer noted, "The food was unbelievable," and the oysters are a must-try. Whether for a casual lunch or an elegant dinner, River House will exceed expectations.

A photo of Repeal Oak Fired Steakhouse restaurant

3. Repeal Oak Fired Steakhouse

4.8

Exceptional(2674)

$$$$Price: Expensive

• Southern american • Downtown Louisville

Booked 81 times today

Repeal Oak Fired Steakhouse in downtown Louisville is where American cuisine reaches new heights, offering an authentic and superb dining experience. Known for its oak-fired steaks, which are "the best in Louisville," this restaurant has a "fantastic" reputation for both food and service. Guests rave about the juicy, tender steaks and the unique use of reclaimed American Oak bourbon barrels that infuse each dish with rich, smoky flavors. The ambiance complements the exceptional culinary offerings, making every visit a memorable one. "Highly recommended" for its impeccable service, Repeal is a must-visit destination for anyone craving genuine American cuisine.

4. Le Moo

4.7

Exceptional(5869)

$$$$Price: Expensive

• Southern american • Highlands - Bardstown Rd / Taylorsville Rd

Booked 29 times today

Le Moo, nestled in the vibrant Highlands neighborhood of Louisville, is renowned for its exquisite seafood cuisine that captivates taste buds with every bite. Critics and diners alike rave about the "fantastic dining experience" and "delicious food," making it a top choice for seafood lovers. The restaurant's commitment to quality is evident in its fresh, meticulously prepared dishes that showcase the finest catches. The ambiance is cozy and elegant, offering an ideal backdrop for savoring the ocean's bounty. With attentive service and a reputation for culinary excellence, Le Moo promises an unforgettable seafood dining adventure that leaves patrons eager to return.

5. Mesh - Louisville

4.7

Exceptional(3653)

$$$$Price: Moderate

• Southern american • St Matthews

Booked 45 times today

Mesh - Louisville, located in the heart of St Matthews, is a beacon for Seafood aficionados seeking an exceptional dining experience. Renowned for its "delicious seafood special" featuring shrimp and scallops over angel hair pasta, Mesh crafts every dish with a commitment to quality and authenticity that is truly unparalleled. Guests rave about the "excellent crab cake special" and the "superb fish dip," highlighting the restaurant's dedication to showcasing the freshest ingredients. The elegant yet comfortable ambiance complements the exquisite flavors, making Mesh an ideal destination for any occasion. With consistently "great service" and "wonderful food," Mesh is a standout choice for seafood lovers.

6. The Last Refuge

4.6

Exceptional(117)

$$$$Price: Expensive

• Southern american • West Louisville

Booked 18 times today

The Last Refuge in West Louisville is a stunning testament to authentic American cuisine, offering a unique dining experience set within a beautifully renovated historic church. With "phenomenal food and drinks" that perfectly capture the essence of American flavors, diners rave about the "incredible Chicago-style pizza" and a "fantastic whiskey selection" that showcases true American craftsmanship. The ambiance is a delightful blend of elegance and history, creating a "warm and relaxing atmosphere" that leaves a lasting impression. Guests are enchanted by the "gorgeous venue" and "swanky vibes," making it a must-visit for those seeking a true taste of America.

7. Proof on Main

4.6

Exceptional(3809)

$$$$Price: Expensive

• Southern american • Downtown Louisville

Booked 31 times today

The ingredients in our menus reflect the region’s sustainable farmers and producers with a soulful and honest approach showcasing the bounty of the Ohio River Valley. Housed in five historic buildings in downtown Louisville, Proof on Main is part of 21c Museum Hotels, the award-winning boutique hotel and restaurant group. The dining room is one of the most striking public spaces in the city, with rotating, contemporary art exhibitions by local and internationally-acclaimed artists alike.

A photo of Vincenzo's Italian Restaurant restaurant

8. Vincenzo's Italian Restaurant

4.8

Exceptional(3803)

$$$$Price: Expensive

• Southern american • Downtown Louisville

Booked 21 times today

Vincenzo's Italian Restaurant, nestled in the heart of downtown Louisville, is a hidden gem that brilliantly showcases the rich tapestry of authentic American cuisine. Known for its impeccable service and delightful ambiance, Vincenzo's has consistently received rave reviews from patrons who describe their experiences as "over the top" and "absolutely fantastic." The restaurant's dedication to quality is evident in every dish, with many diners praising the "delicious and inventive" meals that leave a lasting impression. Whether it's a special occasion or an intimate dinner, Vincenzo's promises an exceptional American dining experience that "never disappoints."

A photo of Doc Crow's Southern Smokehouse & Raw Bar restaurant

9. Doc Crow's Southern Smokehouse & Raw Bar

4.5

Awesome(1564)

$$$$Price: Expensive

• Southern american • Downtown Louisville

Booked 43 times today

Doc Crow's Southern Smokehouse & Raw Bar in Downtown Louisville is a haven for barbecue enthusiasts, offering a "magnificent" culinary experience that captures the heart of Southern barbecue. Known for its "juicy" pulled pork and "delicious" ribs, Doc Crow's stands out with its authentic barbecue flavors complemented by a vibrant atmosphere and outstanding service. Diners rave about the "great food" and "super atmosphere," making it a go-to destination for locals and visitors alike. With a "huge bourbon selection" enhancing the dining experience, Doc Crow's ensures every meal is memorable, making it a must-visit for anyone seeking genuine Southern barbecue delights.

10. Varanese

4.8

Exceptional(4675)

$$$$Price: Moderate

• Southern american • Frankfort Ave - Crescent Hill

Booked 12 times today

Varanese, nestled in the vibrant Frankfort Ave of Louisville, is a beacon of exquisite Seafood cuisine. Diners rave about the "caramelized orange salmon," a standout dish that epitomizes the restaurant's commitment to fresh, high-quality ingredients and inventive flavors. The eclectic menu is enriched by a rich tapestry of culturally diverse offerings, ensuring there's something for every palate. The "best shrimp and grits" ever tasted, as one diner enthused, highlight the restaurant's prowess in delivering authentic and flavorful Seafood. With its inviting ambience, live jazz, and attentive service, Varanese promises a dining experience that's both memorable and delightful.

‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

See what locals rave about

From verified diners like you

T
Tyler
Central Kentucky •1 review
5.0
Dined 3 days ago
Well worth a trip to this place. Service and food was amazing, along with a great conversation with the owner towards the end of the meal.
More info
Fork & BarrelPrice: Moderate• American• Frankfort Ave - Crescent Hill
•
4.5
T
Tina
Central Kentucky •2 reviews
4.0
Dined 3 days ago
Our sides were cold but still good. Service was good. It was EXTREMLY noisy. There was a party upstairs and we could barely hear each other speak it our server. Not my best experience there.
More info
The Eagle - HighlandsPrice: Expensive• Southern• Highlands - Bardstown Rd / Taylorsville Rd
•
4.7
K
Kristi
Nashville •2 reviews
5.0
Dined 3 days ago
Very cool place and the food and service was great!
More info
Doc Crow's Southern Smokehouse & Raw BarPrice: Expensive• Southern• Downtown Louisville
•
4.5
W
william
New York City •12 reviews
5.0
Dined 4 days ago
Great time and great service, will be back again!!!
More info
Sway - Hyatt Regency LouisvillePrice: Moderate• Southern• Downtown Louisville
•
4
M
Melissa
Central Kentucky •9 reviews
5.0
Dined 4 days ago
Celebrating 20 years in business, Bourbons Bistro delivers exceptional food consistently. Our party enjoyed the pork chop, shrimp & grits and steak frites. We requested sharing plates & tested each others meals. All were delicious. The chef visited tables & we were able to rave about his creations. Our table did rave over the grits multiple times. Our food server Megan delivered great service. Come early & enjoy the famous bourbon bar. Mike the bartender is so knowledgeable & a fun host. We had a memorable evening.
More info
Bourbons BistroPrice: Moderate• Southern• Frankfort Ave - Crescent Hill
•
4.7

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Neighborhood
Cuisine Nearby
Southern american Cuisine

Jeffersonville

Southern american

Jeffersonville
St Matthews
Portland
Lexington
New Albany
Midway
Elizabeth
Starlight, IN
Clarksville
South Louisville
Jeffersontown
Bardstown
Kentucky
East Market St - NuLu
Nicholasville
Westport Rd - Lyndon
Downtown Louisville
Highlands - Bardstown Rd / Taylorsville Rd
West Buechel
West Louisville