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Best Comfort Food Restaurants in Medical Center

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16 restaurants available nearby

A photo of Whiskey Cake - San Antonio restaurant
1. Whiskey Cake - San Antonio
4.8
Exceptional(4181)
Price: Moderate
• Farm-to-table • La Cantera
Booked 62 times today
Whiskey Cake in San Antonio is a comfort food haven. The restaurant's approachable menu features New American comfort food, sourcing as much as possible locally. Signature dishes include slow-cooked meats and the famous whiskey cake for dessert. The farm-to-fork mission is evident in the fresh, high quality ingredients. Reviewers consistently mention the 'comfort food' options, 'fresh and light yet feel like comfort foods', and 'great food always consistent with awesome flavors'. The restaurant's inviting atmosphere, great service, and unique menu add to the comfort food experience.
A photo of Southerleigh Fine Food & Brewery restaurant
2. Southerleigh Fine Food & Brewery
4.8
Exceptional(3078)
Price: Moderate
• Southern • Downtown
Booked 48 times today
Southerleigh Fine Food & Brewery, helmed by San Antonio Chef Jeff Balfour, brings a modern take on Texas' cross-cultural cuisine to Pearl. Influenced by the coastal classics of Chef Balfour's upbringing in Galveston married with the comfort of southern cuisine, Southerleigh boasts a curated, seasonally shifting menu that reflects Chef Jeff Balfour's innovative craftsmanship. Southerleigh houses a custom-manufactured brewery designed by Portland Kettle Works and brings brewing back to Pearl offering 15 different beers on tap. Southerleigh is located at 136 East Grayson, Suite 120, on the ground floor in the historic Pearl brewhouse.
A photo of Brasserie Mon Chou Chou restaurant
3. Brasserie Mon Chou Chou
4.8
Exceptional(3356)
Price: Moderate
• French • Downtown
Booked 74 times today
Brasserie Mon Chou Chou is a vibrant place, bustling with energy and celebrated food prepared in a French style, with free-flowing drinks and people connecting over the every day and the special. We feature quintessential French comfort food that showcases simple, earthy, flavorful dishes from regions throughout France. Brasserie Mon Chou Chou is located in the Pearl district near the entrance of the hotel Emma at 312 Pearl Parkway Building 2, Suite 2104, in the space formerly occupied by The Culinary Institute of America's Nao. "Mon Chou Chou" is an affectionate French nickname given to a person who is special to you. Usually a person of unmatched care, love, and beauty who makes your world "go round".
A photo of Best Quality Daughter restaurant
4. Best Quality Daughter
4.8
Exceptional(468)
Price: Moderate
• Unspecified • Downtown
Booked 95 times today
Best Quality Daughter houses a vibrant, chic décor and new, unique Asian-American menu. In 2018, chef Jennifer Hwa Dobbertin, wanting to address the sparsity of Asian-American female chefs in South Texas, developed a new concept through a series of pop-up dinners called Best Quality Daughter with fellow chef Anne Ng and artist Jennifer Ling Datchuk. Today Best Quality Daughter is located in the historic Mueller House at the Pearl Brewery. Curated by chef Jennifer Hwa Dobbertin, Best Quality Daughter's menu takes inspiration from her travels and the comfort food of her youth as a second-generation Chinese-American.
A photo of Ambler - Texas Kitchen + Cocktails restaurant
5. Ambler - Texas Kitchen + Cocktails
4.4
Awesome(537)
Price: Moderate
• Contemporary American • Downtown
Booked 8 times today
Ambler - Texas Kitchen + Cocktails is a comfort food haven with its 'fantastic service' and 'superb meals' praised by reviewers. The 'great food', 'great atmosphere' and 'friendly staff' make it a 'comfortable' spot. The menu, inspired by Texas, boasts 'jaw-dropping views' and 'vibrant flavors'. From 'exotic menu' to 'excellent food and cocktails', Ambler is the perfect spot for a comforting meal.
A photo of Tokyo Cowboy restaurant
6. Tokyo Cowboy
4.5
Awesome(210)
Price: Expensive
• Tapas / Small Plates • Downtown
Booked 37 times today
Asian-inspired diner with creative cocktails and a great selection of whisky!
A photo of Restaurant Claudine restaurant
7. Restaurant Claudine
4.5
Awesome(556)
Price: Moderate
• Contemporary American • Downtown
Booked 13 times today
Restaurant Claudine, Carpenter Carpenter’s third establishment, resides in a remodeled home in the up-and-coming Government Hill neighborhood. The space offers snug tables surrounded by elegant hand-painted wallpaper, vintage chandeliers, and sentimental pictures of our namesake, Houston Carpenter’s grandmother, Claudine. We now offer lunch and dinner Tuesday-Sunday, with Tea Time on Saturday and Sunday morning's. Restaurant Claudine has recently launched a new menu that features New American cuisine for both lunch and dinner.
A photo of Sustenio - Eilan Hotel restaurant
8. Sustenio - Eilan Hotel
4.2
Awesome(687)
Price: Moderate
• Southwest • La Cantera
Enjoy the diverse flavors of South Texas at Sustenio! Local fresh produce and proteins brought in daily; with influences from Traditional Mexico, Creole and Southern Comfort foods.
A photo of Bazille – Nordstrom La Cantera restaurant
9. Bazille – Nordstrom La Cantera
5.0
Exceptional(98)
Price: Moderate
• Contemporary American • La Cantera
Booked 4 times today
Bold flavors elevate beloved bistro classics in chic and inviting Bazille. Meet up with friends at the bar for internationally sourced wines and handcrafted cocktails. Stay for appetizers, salads, brick-oven pizzas and our tempting housemade desserts.The Bazille is located on level 2 inside Nordstrom at The Shops at La Cantera. Join us for Brunch on weekends.
A photo of Joe's Crab Shack - San Antonio restaurant
10. Joe's Crab Shack - San Antonio
3.6
Very Good(16)
Price: Moderate
• Seafood • Downtown
Booked 13 times today
Joe’s Crab Shack offers a variety of favorites from all parts of the sea and shore. From its extensive menu, guests can choose from buckets of seasonal seafood, fried shrimp platters and fish dishes, as well as options from the “mainland” that include steak, sandwiches, and chicken. Guests can indulge in over-sized and creative cocktails, such as the Shark Bite which is playfully garnished with a shark toy. Since its inception, Joe’s popularity has stemmed not only from its menu, but also its retail store. With various pieces of merchandise for purchase, including the ever-popular tie-dye T-shirt with the phrase “Peace, Love and Crabs,” Joe’s has become synonymous with the word “fun.”
‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

See what locals rave about

From verified diners like you
From verified diners like you
  • Elizabeth
    San Antonio •13 reviews
    5.0
    Dined 2 days ago
    As always, food and service were exceptional! Enjoyed a cocktail at the bar while waiting for our table. Best dirty martini I’ve had in a while! My favorite: Snapper Throats 👍🏼
    More info
    Southerleigh Fine Food & BreweryPrice: Moderate• Southern• Downtown
    •
    4.8
  • Heather
    San Antonio •1 review
    5.0
    Dined 2 days ago
    Wonderful experience. Some of the best food and drinks in San Antonio. The atmosphere was amazing; and of course hospitality and service was phenomenal.
    More info
    Whiskey Cake - San AntonioPrice: Moderate• Farm-to-table• La Cantera
    •
    4.8
  • Steven
    Dallas - Fort Worth •1 review
    5.0
    Dined 4 days ago
    We went here for our 13th wedding anniversary. Where to start? Immediately, we were sat given complementary champagne. Our waitress Jewles was wonderful!!! Very, very on point. Checked on us frequently went out of her way on one of our requests. There was a small hickup with my husband's order, but right away, a manager came to explain the situation and wasn't a big deal to us, just more tad of a wait. Then 2 free desserts to end the night!!! Honestly, the whole night was good and food amazing! Jewels was 10+ stars for her waiting services if I could give that! Will definitely be back!
    More info
    Brasserie Mon Chou ChouPrice: Moderate• French• Downtown
    •
    4.8
  • Patricia
    Minneapolis - St. Paul •9 reviews
    5.0
    Dined 6 days ago
    First-time visitors, we thoroughly enjoyed our meal on the patio at Best Quality Daughter. We shared the “smallish” plates: Smashed Cucumbers, the Impossible Potstickers, and the Creamy Coconut Tom Yum Noodles. By then, we were stuffed and must stop here again for more amazing dishes! We also brought home T-shirts for our own three “best quality daughters.” Thank you for a fabulous time!
    More info
    Best Quality DaughterPrice: Moderate• undefined• Downtown
    •
    4.8
  • Phil
    Phoenix / Arizona •5 reviews
    5.0
    Dined on Nov 10, 2024
    Unique experience to have a Texas style meal outside on the Riverwalk. Meal was excellent and the service was great. Highly recommend having this dinner.
    More info
    Ambler - Texas Kitchen + CocktailsPrice: Moderate• Contemporary American• Downtown
    •
    4.4

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