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Best Comfort Food Restaurants in Medical Center

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17 restaurants available nearby

A photo of Whiskey Cake - San Antonio restaurant
1. Whiskey Cake - San Antonio
4.8
Exceptional(4206)
Price: Moderate
• Farm-to-table • La Cantera
Booked 151 times today
Whiskey Cake in San Antonio is a comfort food haven. The restaurant's approachable menu features New American comfort food, sourcing as much as possible locally. Signature dishes include slow-cooked meats and the famous whiskey cake for dessert. The farm-to-fork mission is evident in the fresh, high quality ingredients. Reviewers consistently mention the 'comfort food' options, 'fresh and light yet feel like comfort foods', and 'great food always consistent with awesome flavors'. The restaurant's inviting atmosphere, great service, and unique menu add to the comfort food experience.
A photo of Southerleigh Fine Food & Brewery restaurant
2. Southerleigh Fine Food & Brewery
4.8
Exceptional(3105)
Price: Moderate
• Southern • Downtown
Booked 73 times today
Southerleigh Fine Food & Brewery, helmed by San Antonio Chef Jeff Balfour, brings a modern take on Texas' cross-cultural cuisine to Pearl. Influenced by the coastal classics of Chef Balfour's upbringing in Galveston married with the comfort of southern cuisine, Southerleigh boasts a curated, seasonally shifting menu that reflects Chef Jeff Balfour's innovative craftsmanship. Southerleigh houses a custom-manufactured brewery designed by Portland Kettle Works and brings brewing back to Pearl offering 15 different beers on tap. Southerleigh is located at 136 East Grayson, Suite 120, on the ground floor in the historic Pearl brewhouse.
A photo of Best Quality Daughter restaurant
3. Best Quality Daughter
4.8
Exceptional(508)
Price: Moderate
• Unspecified • Downtown
Booked 103 times today
Best Quality Daughter houses a vibrant, chic décor and new, unique Asian-American menu. In 2018, chef Jennifer Hwa Dobbertin, wanting to address the sparsity of Asian-American female chefs in South Texas, developed a new concept through a series of pop-up dinners called Best Quality Daughter with fellow chef Anne Ng and artist Jennifer Ling Datchuk. Today Best Quality Daughter is located in the historic Mueller House at the Pearl Brewery. Curated by chef Jennifer Hwa Dobbertin, Best Quality Daughter's menu takes inspiration from her travels and the comfort food of her youth as a second-generation Chinese-American.
A photo of Tenfold Rooftop restaurant
4. Tenfold Rooftop
4.5
Awesome(96)
Price: Expensive
• International • Downtown
Booked 84 times today
One of San Antonio’s most distinguished open-air venues, Tenfold Rooftop has garnered quite the buzz as an upcoming luxury, year-round locale—where every statement it makes packs 10x the punch. The bar’s playful cocktail list highlights tequila and mezcal, offering drinks that range from boozy to frozen to refreshing. Embark on a culinary adventure with Tenfold's exclusive '10x Tour'—a prix fixe menu featuring 10 chef-selected dishes from 10 different regions around the world. This curated experience promises to elevate your dining journey, making it 10x better than the rest.
A photo of Ambler - Texas Kitchen + Cocktails restaurant
5. Ambler - Texas Kitchen + Cocktails
4.3
Awesome(556)
Price: Moderate
• Contemporary American • Downtown
Booked 35 times today
Ambler - Texas Kitchen + Cocktails is a comfort food haven with its 'fantastic service' and 'superb meals' praised by reviewers. The 'great food', 'great atmosphere' and 'friendly staff' make it a 'comfortable' spot. The menu, inspired by Texas, boasts 'jaw-dropping views' and 'vibrant flavors'. From 'exotic menu' to 'excellent food and cocktails', Ambler is the perfect spot for a comforting meal.
A photo of Brasserie Mon Chou Chou restaurant
6. Brasserie Mon Chou Chou
4.8
Exceptional(3402)
Price: Moderate
• French • Downtown
Booked 77 times today
Brasserie Mon Chou Chou is a vibrant place, bustling with energy and celebrated food prepared in a French style, with free-flowing drinks and people connecting over the every day and the special. We feature quintessential French comfort food that showcases simple, earthy, flavorful dishes from regions throughout France. Brasserie Mon Chou Chou is located in the Pearl district near the entrance of the hotel Emma at 312 Pearl Parkway Building 2, Suite 2104, in the space formerly occupied by The Culinary Institute of America's Nao. "Mon Chou Chou" is an affectionate French nickname given to a person who is special to you. Usually a person of unmatched care, love, and beauty who makes your world "go round".
A photo of Tokyo Cowboy restaurant
7. Tokyo Cowboy
4.6
Exceptional(230)
Price: Expensive
• Tapas / Small Plates • Downtown
Booked 76 times today
Asian-inspired diner with creative cocktails and a great selection of whisky!
A photo of Esquire Tavern restaurant
8. Esquire Tavern
4.4
Awesome(648)
Price: Expensive
• American • Downtown
Booked 29 times today
Located in the heart of downtown, The Esquire Tavern is the oldest bar on the San Antonio Riverwalk, opened the year, month and day that Prohibition was repealed. Tending bar in the early days was a highly prized and much sought after craft. Bar keeps then created many of their own syrups, mixes and concoctions and used the freshest of juices with the intention of serving the best products. We at the Esquire have taken a serious approach to the old world of bartending and spun it with a modern twist. Combining classic techniques and new world flavors and culinary concepts, our goal is to lead and set San Antonio's emerging cocktail culture on the map.
A photo of Joe's Crab Shack - San Antonio restaurant
9. Joe's Crab Shack - San Antonio
3.6
Very Good(18)
Price: Moderate
• Seafood • Downtown
Booked 46 times today
Joe’s Crab Shack offers a variety of favorites from all parts of the sea and shore. From its extensive menu, guests can choose from buckets of seasonal seafood, fried shrimp platters and fish dishes, as well as options from the “mainland” that include steak, sandwiches, and chicken. Guests can indulge in over-sized and creative cocktails, such as the Shark Bite which is playfully garnished with a shark toy. Since its inception, Joe’s popularity has stemmed not only from its menu, but also its retail store. With various pieces of merchandise for purchase, including the ever-popular tie-dye T-shirt with the phrase “Peace, Love and Crabs,” Joe’s has become synonymous with the word “fun.”
A photo of Sustenio - Eilan Hotel restaurant
10. Sustenio - Eilan Hotel
4.2
Awesome(693)
Price: Moderate
• Southwest • La Cantera
Booked 3 times today
Enjoy the diverse flavors of South Texas at Sustenio! Local fresh produce and proteins brought in daily; with influences from Traditional Mexico, Creole and Southern Comfort foods.
‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

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