Enable JavaScript to run this app.
Skip to main content
OpenTable logo
  1. Home
  2. United States
  3. St. Louis
  4. Midtown
  5. University City
Diego's Cantina, University City, MO

Diego's Cantina

4.7
4.7
472 Reviews
$30 and under
Mexican

Make a reservation

2 people
10:00 PM
Booked 17 times today
  • Charming
  • Innovative
  • Healthy
Owned and operated by Natasha Kwan, St. Louis Post Dispatch's Best Chef in St. Louis, our elevated Mexican restaurant blends vibrant flavors with a tropical atmosphere that feels like a vacation, taking you far from St. Louis. We’re located in a charming University City neighborhood, just steps from Clayton.

Our menu features plates like queso flameado, costra and crunch tacos, enchiladas, nachos and a few Tex-Mex options. Cocktails and margaritas are crafted with fresh-squeezed juices and premium ingredients.


We offer all-day happy hour Tuesday through Thursday. We also accommodate parties of 10 or more for special celebrations.

Other accolades:
Best New Restaurant, A-List Restaurant (St. Louis Magazine)
Best Queso (Ian Froeb of St. Louis Post-Dispatch)

To Note:
Gluten free friendly - our fryer is dedicated gluten free so eat all the chips you want!
Many vegan options
Dog friendly patio and sidewalk

Order delivery or takeout

Dining areas

Additional information

  • Dining style
    Casual Dining
  • Price
    $30 and under
  • Cuisines
    Mexican, Tex-Mex, Tapas / Small Plates
  • Hours of operation
    Fri, Sat 12:00 pm–10:00 pm Bar Tue–Thu 4:00 pm–10:00 pm Fri, Sat 12:00 pm–11:00 pm Dinner Tue–Thu 4:00 pm–9:00 pm
  • Phone number
    (314) 553-9906
  • Payment options
    AMEX, Discover, Mastercard, Visa
  • Dress code
    Casual Dress
  • Executive chef
    Natasha Kwan
  • Neighborhood
    University City
  • Cross street
    Delmar
  • Parking details
    Street Parking
  • Additional
    Beer, Cocktails, Full Bar, Gender Neutral Restroom, Gluten-free Options, Happy Hour, Non-Smoking, Patio/Outdoor Dining, Patio/Outdoor Dining, Takeout, Vegan, Wheelchair Access, Wine

What 472 people are saying

Overall ratings and reviews

Reviews can only be made by diners who have eaten at this restaurant

4.7
4.7 based on recent ratings
  • 4.7Food
  • 4.7Service
  • 4.7Ambience
  • 4.5Value

NoiseModerate

Loved For

  • St. Louis

    Kid-friendly

  • St. Louis

    Innovative

  • St. Louis

    Healthy

  • St. Louis

    Great for outdoor dining

  • Midtown

    Best Ambiance

  • Midtown

    Great for brunch

  • Midtown

    Innovative

  • Midtown

    Good for groups

  • Midtown

    Healthy

  • Midtown

    Neighborhood gem

  • Midtown

    Great for outdoor dining

  • Midtown

    Romantic

  • Midtown

    Lively

Review summary

AI-generated from verified diner reviews
Diego's Cantina offers a fresh twist on Mexican cuisine, with "delicious food" and "top notch margaritas." The ambiance is vibrant, and the staff is "attentive and knowledgeable." Ideal for gluten-sensitive diners, it features a diverse menu with healthy options. Perfect for date nights or group gatherings.

472 Reviews
  1. Charles Hoffman

    VIP

    St. Louis

    39 reviews

    5.0

    39 reviews

    Dined 2 days ago

    1. Overall 5
    2. Food 4
    3. Service 5
    4. Ambience 3
    More authentic Mexican than most. Service was outstanding as usual. Comfortable, friendly place.

    Is this helpful?

  2. Lewis

    St. Louis

    1 review

    5.0

    1 review

    Dined on November 27, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Delicious food that makes vegan dishes taste great for a non-vegan eater! fresh twist on Mexican food in a lovely location. Recommend!

    Is this helpful?

  3. Marc

    VIP

    Kansas City

    21 reviews

    5.0

    21 reviews

    Dined on November 2, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    I have gone many times. The restaurant never disappoints. Servers are terrific. They are the perfect mix of friendly, professional, and helpful. The food taste really good always seems freshly prepared. The heat throughout the food seems very consistent so I doubt they use a microwave or other to reheat food—if I am wrong they are best reheaters there ever were! Atmosphere is just right. Enjoyable casual and prices in today’s world are pretty darn good! Highly recommend

    Is this helpful?

  4. Laurie

    St. Louis

    1 review

    5.0

    1 review

    Dined on November 2, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Delicious and fresh twist on Mexican food in a lovely location. Recommend!

    Is this helpful?

  5. James

    Dallas

    1 review

    5.0

    1 review

    Dined on October 25, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Delicious food and drinks at really good prices. Lots of healthy and vegetarian options as well. Will definitely be going back.

    Is this helpful?

  6. Mayte

    VIP

    Memphis/West TN

    35 reviews

    5.0

    35 reviews

    Dined on October 25, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 4
    Great space for a large party. Great service and good!

    Is this helpful?

  7. Haley

    VIP

    St. Louis

    4 reviews

    4.0

    4 reviews

    Dined on October 24, 2024

    1. Overall 4
    2. Food 5
    3. Service 1
    4. Ambience 5
    The food is always delicious! There were seven of us and a 20% gratuity was automatically added to our check. which we all kind of were irritated about because we were not told ahead of time. She also could not split up our check. We waited about 40 minutes to order dessert and then another 30 minutes to actually get our checks. It seems like there was one person, seating tables, taking orders, and bringing the food out. Food is delicious. They need more staff

    Is this helpful?

  8. Robin

    VIP

    Raleigh

    14 reviews

    5.0

    14 reviews

    Dined on September 28, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Truly delicious food! The margaritas were top notch!! Beautiful restaurant, tastefully decorated without being kitschy. Would definitely return!

    Is this helpful?

  9. Brendan

    Washington DC

    1 review

    5.0

    1 review

    Dined on September 21, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Great food with lots of options. The service was good too.

    Is this helpful?

  10. Elin

    St. Louis

    16 reviews

    5.0

    16 reviews

    Dined on September 19, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Me and my friends come here once every couple months for a girls night and it never disappoints. The service is always great. The food is always great. The ambience is always great. Thank you!

    Is this helpful?

FAQs

Diego's Cantina offers takeout which you can order by calling the restaurant at (314) 553-9906.

Diego's Cantina is rated 4.7 stars by 472 OpenTable diners.

Yes, you can generally book this restaurant by choosing the date, time and party size on OpenTable.

Make a reservation

2 people
10:00 PM
Booked 17 times today

Order delivery or takeout

Google Map for Diego's Cantina

630 North & South Road, University City, MO 63130

Dining areas

Additional information

  • Cross street
    Delmar
  • Neighborhood
    University City
  • Hours of operation
    Fri, Sat 12:00 pm–10:00 pm Bar Tue–Thu 4:00 pm–10:00 pm Fri, Sat 12:00 pm–11:00 pm Dinner Tue–Thu 4:00 pm–9:00 pm
  • Price
    $30 and under
  • Cuisines
    Mexican, Tex-Mex, Tapas / Small Plates
  • Dining style
    Casual Dining
  • Dress code
    Casual Dress
  • Parking details
    Street Parking
  • Payment options
    AMEX, Discover, Mastercard, Visa
  • Executive chef
    Natasha Kwan
  • Additional
    Beer, Cocktails, Full Bar, Gender Neutral Restroom, Gluten-free Options, Happy Hour, Non-Smoking, Patio/Outdoor Dining, Patio/Outdoor Dining, Takeout, Vegan, Wheelchair Access, Wine
  • Privacy Policy
  • Terms of Use
  • Cookies and Interest-Based Ads
  • Cookie Preferences
Copyright © 2024 OpenTable, Inc. 1 Montgomery St Ste 500, San Francisco CA 94104 - All rights reserved.
OpenTable is part of Booking Holdings, the world leader in online travel and related services.
Booking Logo
Priceline Logo
KAYAK Logo
Agoda Logo
OpenTable Logo